CLINICAL SIGNIFICNCE OF T-31C POLYMORPHISM OF IL-1β GENE IN RECURENT BRONCHITIS IN CHILDREN
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Keywords

recurrent bronchitis, lymphatic-hypoplastic diathesis, gene polymorphisms, cytokines

Abstract

The analysis of the associative relationship of the gene polymorphism in the IL-1β promoter region in positions (T-31C) with the risk of developing RB in 93 children with recurrent bronchitis aged 2 to 7 years and in 110 apparently healthy children of the same age in the Uzbek population.

         The results of the study showed statistically significant differences in the frequency distribution of alleles and genotypes of the -31 T> C polymorphic locus of the IL-1β gene in patients with RB. The frequency of the unfavorable C and C / C allele of the genotype was significantly more often determined in RB patients against the background of LGD, which indicates a predisposing role of the rs 1143627 polymorphism of the IL-1β gene to the development of recurrent bronchitis in children of the Uzbek population was carried out.

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