Abstract
The aim of our study was to evaluate the role of polymorphism rs17576 MMP-
9 gene in patients with type 2 diabetes mellitus after myocardial infarction (MI). In
patients with type 2 diabetes mellitus after myocardial infarction 86 Uzbeks have been
studied the alleles and genotypes rs17576 MMP-9 gene. According to it, according to the
result of the oddsratio (OR - odds ratio), in carriers of the minor allele G the probability
of developing the disease decreased by 29% (OR =0.71, 95% CI: 0.45-1.12), this means
that the minor allele G has a protective effect against the development of coronary heart
disease. On the other hand, the wild-type A allele of the MMP-9 gene polymorphism
rs17576 increased the like-lihood ofdeveloping MI by 42% (OR = 1.42; 95% CI: 0.91-
2.21) and turned out to be a significant risk factor for developing MI.
