PATHOGENETIC SIGNIFICANCE OF BIOCHEMICALLY ASSOCIATED WITH HEMOSTASIS OF PHALATE CYCLE FII AND FV GENES IN DIAGNOSIS OF PERIVENTRICULAR LEUKOMALATION IN CHILDREN.

Abstract

A number of studies are being carried out in the world aimed at improving the efficiency of diagnosis and treatment of clinical and pathogenetic parallels of periventricular leukomalacia in children. In this regard, the issues of determining the frequency and nature of neurological disorders, the structure of complications in children with periventricular leukomalacia, studying the role of the condition, the course of individual clinical signs and determining the prognosis in periventricular leukomalacia complicated by periventricular hemorrhage are relevant. Also of particular importance is the identification of the presence of an association between polymorphic variants of candidate genes in PVL: factor V Leiden, prothrombin G20210A factor II, study of the frequency and structure of complications in children with PVL and periventricular hemorrhage (PVH), depending on the nature of the "gene-gene interactions" and genotypic combinations, development of a methodology and study of information content for the diagnosis and prediction of the course of vascular disorders of hemorrhagic and ischemic nature in PVL using available neurophysiological research methods.