Abstract
In children, glomerulonephritis is a disease characterized by rapid progression
and complication caused by an irreversible process of the renal glomeruli. Currently,
methods of molecular diagnostics have begun to actively develop, which not only complement
traditional research methods, but also provide insight from the point of view of molecular
pathophysiology. It is expected that a key role in the diagnosis of kidney disease is played
by the identification of genes and their changes in the course of the disease, which predict
the course of the disease. Changes in chromosomal polymorphic genes of matrix
metalloproteinase and its tissue inhibitors, as well as how this change manifests itself in
chronic glomerulonephritis, were determined in the prognosis of the disease.