Abstract
Chronic obstructive pulmonary disease (COPD) in modern medicine is one of
the most common non-infectious diseases in the territory of the Republic of Uzbekistan.
Thrombotic events are a common cause of hospitalizations and death in this category of
patients.To clarify the etiology of frequent thrombosis in patients with COPD, the authors
studied the occurrence of the Asp919Gly (A / G) polymorphism of the MTR gene as a cause
of thrombophilia on the background of hyperhomocysteinemia as a state of high
hypercoagulable risk.In the course of the study, the author established an association
between the occurrence of this polymorphism among COPD patients with a history of
thrombosis compared with patients without thrombotic complications, which is a sign of a
causal relationship between the presence of a predisposing gene genotype and the development
of thrombosis in this category of patients.