Keywords
Abstract
The aim of this article was to assess the intensity of endogenous intoxication
syndrome in children with advanced appendicular peritonitis. To achieve this goal, 402
children with advanced appendicular peritonitis were examined. Clinical and laboratory
studies included interpretation of general blood analysis data, including calculation of the
leukocyte intoxication index, neutrophil nuclear segmentation index, and spontaneous
white blood cell agglomeration íindex on the 1st, 2nd, 3rd, and 4th days of the disease. The
degree of endogenous intoxication was judged by the level of average plasma molecules. The
activity of superoxide dismutase and catalase in blood serum were determined. Studies of
hemostasis parameters were also conducted.
As a result of the conducted studies, it was found that the pronounced inflammatory
process and endotoxicosis that inevitably accompanies RAP have a direct effect on the
platelet link of hemostasis, which can be a prerequisite for disorders in the microcirculation
system, aggravating both the damage to the peritoneum and increasing the risk of intra -
and postoperative complications.