Keywords
non-alcohol fatty liver disease, genetic factors, pathogenesis, liver fibrosis, liver cirrhosis
Abstract
The steady increase in the prevalence of non-alcohol fatty liver disease (NAFLD),
the appearance of rapidly progressive forms with transformation into liver cirrhosis and
hepatocellular carcinoma (HCC) dictate the need for a deeper study of the mechanisms of
liver damage. The known facts of the interaction of systemic insulin resistance with the
development of fatty liver degeneration cannot fully explain the evolution of the clinical
course of this pathology. This review presents the results of a recent study revealing the
genetic, molecular aspects of the development and progression of this disease, which,
according to forecasts, will soon become the leading cause of end-stage liver disease.