ANALYSIS OF THE ROLE OF THE C807T POLYMORPHISM OF THE ITGA2 GENE WITH THE DEVELOPMENT OF VASCULAR THROMBOSES OF DIFFERENT LOCALIZATIONS
Keywords:
deep vein thrombosis of the lower extremities, ischemic stroke, myocardial infarction, genetic polymorphism C807T ITGA2Abstract
The analysis of the genetic factor of the risk of developing vascular thrombosis of various localizations was carried out in 107 patients by studying the frequency of distribution of alleles and genotypes of the C807T polymorphism in the integrin alpha-2 (ITGA2) gene. In both groups, the actual distribution of C807T polymorphism genotypes corresponded to those expected at the Hardy-Weinberg equilibrium (p<0.05). A significant relationship was established between the risk of developing vascular thrombosis of various localization and the distribution of predisposing/protective variants of the C807T polymorphism genotypes in the ITGA2 gene. These data allow us to propose testing of this locus to predict the risk of thrombogenic complications in vascular thrombosis of various localizations (such as DVT, IS and MI).
