OPTIMIZATION OF APPROACHES TO EARLY PHENOTYPIC DIAGNOSIS AND AN ALGORITHM FOR DIFFERENTIATED MANAGEMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

The practice of managing patients with COPD is determined not only by the approaches of early diagnosis, but also to a greater extent by the number of exacerbations, the number of exacerbations requiring hospitalization, and the assessment of the impact of the disease on the patient's daily life and health. For the most part, these indicators are subjective, and the clinical features of the course of respiratory pathology do not always allow us to focus on the likelihood of respiratory exacerbation and the reason for hospitalization from exacerbation.
The results of our research have shown that the number of exacerbations and the number of exacerbations requiring hospitalization in patients with COPD correlates with a morphological marker - a violation of mucociliary clearance and the depth of its violations. When assessing the relationships, a positive relationship of the average strength between the time of elimination of the agent with the number of exacerbations (r = 0.37) and the number of hospitalizations (r = 0.45) was noted.