DIAGNOSTICS OF LEUKEMIA BY BIOLOGICAL MICROCHIP FOR ANALYSIS OF MLL TRANSLOCATIONS

Abstract

Translocations involving the MLL gene are common in leukemia [1]. MLL plays an important role in the processes of leukemia through the formation of chimeric genes [2, 3], the most frequent of which are MLL-AF4, MLL-ENL, MLL-AF9, MLL-AF10, MLL-ELL, MLL-AF6. Biological microchip research allows for the rapid, accurate and comprehensive detection of MLL gene rearrangements, as well as the precise determination of the fusion point. In this article, we report that biological microarray studies can be used to provide important molecular information that can improve the diagnosis of patients with deukemia. Objective. The role of a biological microchip in the analysis of MLL translocations in leukemia.