DIAGNOSTIC FEATURE OF NEURONSPECIFIC ENOLASIS IN UNDEPENDENT CHILDREN WITH PERINATAL CNS TREATMENT

Abstract

To assess the activity of neuron-specific enolase in premature infants with perinatal CNS damage, depending on gestational age. The level of NSE on average was 86.8 ± 9.7 ng / ml - in newborns of group 1, 64.3 ± 9.0 ng / ml - in newborns of group 2, 56.2 ± 7.3 ng / ml - in children of group 3. The average level of this indicator on the 4th day of life in healthy full-term infants was at the level of 8.8 ± 1.9 ng / ml (p <0.01). From the second week of life, the NSE level was 64.5 ng / ml; 38.4 ng / ml; 26.3 ng / ml; 6.2 ng / ml, respectively. By the end of the early neonatal period, a statistically significant high concentration of serum NSE was recorded in newborns of all examined groups, which confirmed the neurological pathology in these children. Our results allow us to conclude that a pronounced positive relationship between the level of neurospecific markers and the severity of hypoxic damage to the central nervous system at birth persists throughout the neonatal and postneonatal period.