NEUROPSYCHOLOGICAL AND DIFFERENTIAL DIAGNOSTIC FEATURES IN PATIENTS WITH ACQUIRED NON-WILSONIAN DEGENERATION ON THE BACKGROUND OF LIVER CIRRHOSIS

Abstract

In this article, we reviewed acquired non-Wilsonian hepatocerebral degeneration, which is a rare pathology that develops against the background of cirrhosis of the liver, for this reason, many aspects of this disease are not well understood. Including the nature of neuropsychological disorders, which has a diverse clinical picture. The aim of our study was to describe the neuropsychological symptoms in patients with associated acquired non-Wilsonian hepatocerebral degeneration, with liver cirrhosis. 9 patients with liver cirrhosis were examined, 6 of them with portocaval shunting. A clinical neurological study was performed using the UPDRS scale, cognitive impairment was determined using the MoCA test. The content of iron, copper, and manganese in the hair of patients was determined using neutron activation analysis; MRI of the brain was performed. In conclusion, we can say that The picture of neuropsychological disorders was dominated by cognitive impairments of the type of subcortical dementia, a decrease in spatial-visual and long-term memory, emotional and personality disorders in the form of the dominance of apathetic-abulic syndrome, hallucinatory phenomena, depressive and anxiety disorders, obsessive-compulsive disorders. The content of manganese in the hair was increased, while the content of copper, iron, and selenium remained within the control values. The abnormally high signal was detected on T1-weighted images in the basal ganglia, especially in the globus pallidus and, to a lesser extent, in the putamen, subthalamic nucleus, and substantia nigra, but T2-weighted images showed no changes in the basal ganglia, but hyperintense signal changes were detected on T2 with indefinite boundaries in the supratentorial white matter and in the deep white matter of the cerebellum.