A CASE OF ACUTE LYMPHOBLASTIC LEUKEMIA WITH TRANSLOCATION t(1;7) (q41,p22) t(4;12)(q34;q23), +mar.

Abstract

To date, a lot of data has been accumulated proving that chromosome changes in patients with acute lymphoblastic leukemia are of great clinical and prognostic significance. Due to the widespread introduction of the method of differential staining of chromosomes into practice, it became possible to study the karyotype in patients not only at the onset of the disease, but also at different stages of its development. It has been shown that individual chromosomal aberrations are specific for certain types of acute leukemia. A number of chromosomal markers are associated with a favorable prognosis (for example, hyperdiploidy - more than 50 chromosomes in acute lymphoblastic leukemia). Other karyotype disorders, such as, for example, the "Philadelphia" chromosome in acute lymphoblastic leukemia, loss and deletion of chromosomes 5 and 7 in acute non-lymphoblastic leukemia, are prognostically unfavorable aberrations. Of great interest are rare variants of non-random chromosomal disorders, the role of which in the pathogenesis of leukemia is still not clear.