NEW ASPECTS OF THE DIAGNOSIS OF ULCERATIVE COLITIS

Abstract

The purpose of the study was to study the microbial composition of biopsy specimens in ulcerative colitis. Materials and research methods. Microscopy of preparations was carried out after staining with hematoxylin and eosin using a Leika ICC50 HD microscope. Results. A histological and microbiological study of intestinal wall biopsies was performed in 25 patients with ulcerative colitis (n=111). In 83.0% of cases (n=19) a full range of diagnostic features characteristic of ulcerative colitis was determined. In 50% of cases, a pronounced activity of the inflammatory process was observed (n=12), in 30% - moderate (n=7), in 20% - the minimum degree of inflammation activity (n=5). With severe inflammation, a polymorphic picture of changes in the intestinal mucosa was observed. Conclusions. The results obtained allow us to recommend microbiological examination of intestinal wall biopsies in patients with ulcerative colitis, which helps to optimize the choice of antibacterial drugs and monitor the effectiveness of disease therapy.