MORPHOMETRIC CHARACTERISTICS OF THE WALLS OF THE STOMACH AFTER MODELING MILD TRAUMATIC BRAIN INJURY IN WHITE RATS

Abstract

The article states that the study of scientific literature data revealed a lack of information about changes in the morphometric parameters of the walls of the stomach at different periods of traumatic brain injury. It is noted that there are serious deviations in the morphometric parameters of the walls of the stomach in the syndrome of "acute damage to the stomach" after a traumatic brain injury.
Purpose of the research: To conduct a morphometric study of the walls of the stomach in white rats with acute damage to the stomach in different periods of traumatic brain injury.
Materials and research methods. The work was carried out on 135 white outbred rats of 3 months of age of both sexes, weighing about 150-170 grams. A traumatic brain injury was caused by the TBI model "traffic accident". Morphometric changes in the walls of white rats were studied in all periods of traumatic brain injury.
Results of the research: The article states that the syndrome of "acute injury to the stomach" in the acute period of TBI was characterized by an increase in the total thickness of the stomach wall and its mucous membrane, submucosa, height of the gastric glands, smoothing of gastric folds and dimples due to edema and impaired microcirculation in the walls stomach of white rats. These changes persisted in the pyloric part of the stomach until the middle of the intermediate period of TBI. In the third period, a decrease in the thickness of the mucous membrane, the height of the gastric glands, which can be thought of, about the secretory dysfunction of the stomach, was determined. The article describes the correlation of morphometric parameters with periods of TBI. The consequences of morphometric deviations of the walls of the stomach and the timing of their recovery are indicated.
Conclusions: It was found that morphometric changes in the stomach wall are typical in all periods of traumatic brain injury. These morphometric changes occur as a result of a violation of the nervous regulation of the stomach against the background of spasm and a violation of microcirculation in the stomach wall of white rats in response to traumatic brain injury.