DIAGNOSTIC SIGNIFICANCE OF LABORATORY MARKERS, INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES IN THE DEVELOPMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE STEATOSIS AND STEATOHEPATITIS Yuldasheva D.

Abstract

This article studied clinical and laboratory analyzes of 98 patients with non-alcoholic
fatty liver disease. With steatohepatitis, higher ALT and AST values are noted than in patients
with hepatic steatosis. The main differential difference between non-alcoholic steatosis and
steatohepatitis, available in clinical practice, may be the severity of the biochemical syndrome of
cytolysis. The article contains clinical features and prognosis in patients with fatty hepatosis and
non-alcoholic steatohepatitis (NASH). Dyslipidemia (hypertriglyceridemia, decreased HDL,
increased LDL) occurs in about 65-85% of patients. The basal insulin level, according to the results
of our studies, in persons with NAFLD at the stage of steatosis and steatohepatitis was significantly
increased. With NAFLD compared with JS, the level of liver inflammation was rated as higher
with SG activity. It has been proved that there is a correct correlation with the indices of cytolysis,
according to which the functional state of the liver is assessed.