THE IMPACT OF ALCOHOL INTOXICATION COMPLICATED BY TOXIC HEPATITIS ON THE STATE OF THE AUTONOMIC NERVOUS SYSTEM AND COGNITIVE FUNCTIONS

Abstract

The aim of the study: to study the parameters of the autonomic nervous system and cognitive functions in patients with acute alcohol poisoning complicated by toxic hepatitis of varying severity.
Material and Methods
This study included 312 patients with acute alcohol poisoning at the age from 28 to 55 years who were admitted to the Department of Toxicology and Toxicological Reanimation of the RRCEM against the background of chronic alcohol consumption in 2015-2019.
Results and discussion
It follows from the data obtained that in case of mild poisoning, against the background of a short binge, the biochemical parameters were either within the normal range, or showed a slight tendency to increase. All indicators were several times higher than the upper limit of the reference values in patients with moderate and severe poisoning.
Conclusions.
1. In patients with alcohol intoxication, there is a decrease in cognitive functions in proportion to the severity of intoxication and the level of lactate, free ammonia.
2. Patients with a severe degree of alcohol intoxication develop pronounced intellectual impairments that require medical correction, with subsequent mandatory psychological rehabilitation.
3. For acute alcohol poisoning against the background of binge drinking, the development of hypersympathicotonia, caused by an increase in the tone of the sympathetic division of the autonomic nervous system, is characteristic.
4. Indicators of cardiointervalography can be used to diagnose the severity of alcohol intoxication and as predictors of alcoholic delirium.