STATE OF CORTICOTROPHIC FUNCTION IN PATIENTS WITH CS after TSS

Abstract

This article presents the results of a test with desmopressin in 38 patients (including the control group -20) with ACTH-DCS. Of the 18 patients, 77,7% (14patients) are women and 22,2% are men (4patients). The average age of women was 38,85 ± 1,09 years (from 20 to 51 years), men – 31,5 ± 0,25 years (from 31 to 32 years). The duration of the disease was 90,67 months (from 36 to 204 months), the duration before the manifestation was 62,22months (from 6 to 143 months), the duration of the disease from the moment of diagnosis – 29,1 ± 27,76 months (9 to 84 months), the age of patients at the time of diagnosis was on average 35,67 ± 10,49 years (21 to 51), 37,7 ± 1,3 years for women and 28,5 ± 0,25 years in men. In the postoperative period, there was a significant decrease in all hormonal indicators of blood and urine (ACTH, cortisol) compared with preoperative ones.
There were significant differences in pre and postoperative mean values of basal ACTH and cortisol levels after the desmopressin test (p <0.05) in all 18 patients. Thus, in the cohort of postoperative patients with remission of ACTH-DCS in our study with a test with desmopressin, 2 (11%) of 18 patients showed an abnormal increase in the level of ACTH and cortisol, i.e. the test was positive, and this indicates the possible risks of tumor growth and relapse of the disease.