FEATURES OF PHYSICAL DEVELOPMENT AND FORMATION OF THE ENDOCRINE STATUS OF THE OFFSPRING OBTAINED UNDER CONDITIONS OF EXPERIMENTAL HYPOTHYROIDISM IN FEMALES
Keywords:
hypothyroidism of pregnant females, offspring, postnatal ontogenesis, physical development, pituitary - thyroid system, pituitary - testicular system.Abstract
This article is devoted to the identification of features of physical development
and formation of the endocrine status of male rats obtained under conditions of experimental
hypothyroidism of pregnant females.
Hypothyroidism in female rats was induced by oral administration of the anti-thyroid
drug Mercazolil at the rate of 0,5 mg per 100 g of body weight for 21 days. After
establishing a steady decrease in the concentration of free thyroxine in the blood serum, the
females were fertilized by healthy males. During periods of pregnancy and lactation,
females continued to receive a maintenance dose of the drug. We assessed the physical
development and formation of the endocrine status of offspring obtained from females with
experimental hypothyroidism.
It has been established that maternal hypothyroidism leads to a delay in physical
development and a pronounced imbalance of the pituitary - thyroid - testicular system in
their offspring.
