NEUROSPECIFIC MARKERS OF EARLY DIAGNOSIS AND PREDICTION OF PERINATAL CNS LESION IN PREMATURE NEWBORNS
Keywords:
premature newborn, perinatal central nervous system lesion, neurospecific factors, Thompson scale, neurospecific enolase (NSE), brain neurotrophic factor (BDNF), vascular endothelial factor (VEGF)Abstract
The aim of the study was to study the levels of neurospecific proteins NSE, BDNF, VEGF in newborns, depending on the gestation period.
Research materials and methods: 171 newborns with different gestational ages were examined. All children were divided into 3 groups: the 1st main group consisted of 61 premature newborns with gestational age from 32 to 33+6 weeks (33.5±0.11), the 2nd group (comparison) included 60 premature newborns – 34-36+ 6 weeks (35.0±0.11). The control group consisted of 50 newborns with a gestational age of 37+6-40 weeks, whose body weight corresponded to the gestation period. All newborns underwent a thorough obstetric and gynecological anamnesis, a general clinical examination, and an assessment of the state of the nervous system on the Thompson scale "Assessment of the severity of central nervous system damage". In addition, all newborns underwent a study of neurospecific proteins: determination of the concentration of neurospecific enolase (NSE), brain neurotrophic factor (BDNF), vascular endothelial factor (VEGF). Statistical processing of the results was performed by statistical methods using standard ("MS Excel-XP") software tools.
Results: Our research has shown that the diagnosis of neurological disorders in the neonatal period by determining the concentration of neurospecific factors is important for predicting the formation of disabling processes. The results of the study can serve as a supplement in solving the issue of early diagnosis and prognosis of perinatal CNS damage in premature infants.
