ATHEROTHROMBOTIC CEREBRAL STROKES AND MULTIFOCAL ATHEROSCLEROSIS

Authors

  • M.M. Asadullaev.
  • N.M. Vakhabova
  • F.A. Bokiyeva
  • Sh.A. Jangirov

Keywords:

atherothrombotic stroke,multifocal atherosclerosis, atherocalcinosis, microelements, iron, copper, zinc, selenium, cadmium.

Abstract

In this scientific research, information is presented about the role, importance,
quantitative indicators of tissue microelements in the formation of atherothrombotic stroke
and multifocal atherosclerosis, the appearance of various manifestations of atheromatous
plaques,the relationship of the indicator of misbatan fault to each other, as well as quantitative
changes. To clarify this style of information, the results of scientific research conducted by
scientists around the world over the past 10-20 years have been discussed. It turns out that
an increase in the amount of iron in the tissue is a risk factor for cardiovascular diseases.
Iron has a negative effect on the cells involved in the process of atherosclerosis through the
immune system, reduces the pro-inflammatory and anti-inflammatory function of
macrophages. The accumulation of iron in atherosclerotic plaques depends on the fact that
its double-valence manifestation cannot turn into 3 valences. An increase in copper in the
tissue and a decrease in zinc serve as a risk factor for atherosclerosis and ischemic heart
disease.Selenium models inflammation, protects the endothelium, inhibits the oxidation
process, and protects vascular cells from apoptosis and calcification. The negative effects of
cadmium on atherogenesis are associated with increased oxidative stress, inflammation,
endothelial dysfunction, lipid metab

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Published

2023-01-26