COMBINED INTERACTION OF HORMONE GENE POLYMORPHISMS REGULATING THE PROCESS OF SPERMATOGENESIS IN MEN WITH MALE INFERTILITY

Abstract

Combinations of unfavorable allelic variants of the GNRHR (Arg262Gln) and
LHB (G1502A) genes contribute to the formation of male fertility disorders. The combination
of heterozygous genotypes of these genes, which potentiate each other and predispose to
disruption of the spermatogenesis process, has the greatest synergistic effect. Conclusion.
Molecular analysis and a prognostic model based on a combination of unfavorable genotypic
variants of the GNRHR (Arg262Gln) and LHB (G1502A) genes will allow us to assess the
risk of reproductive system disorders and infertility in men.