EVALUATION OF THE SIGNIFICANCE OF THE G/A POLYMORPHISM OF THEF7 GENE IN THE DEVELOPMENT OF AN UNFAVORABLE IVF OUTCOME IN WOMEN WITH THROMBOPHILIA

Abstract

Abstract: The article presents the results of molecular genetic studies полиморфизма of the G/A polymorphism F7 of the F7 90 gene in patients with unsuccessful IVF in women with thrombophilia. The results of the study showed that the A and hetero - G/A allele and homozygous non-functional A / A genotypes полиморфизма of theF7 polymorphism are one of the markers of an increased risk of thrombophilia in women of the Uzbek population. And the functional allele G and the functionally favorable genotype G/G are functional genotypes for the development of pathology (χ2=15.48; p<0.0004; OR=0.03; 95%CI0.00-0.46).
Keywords: thrombophilia, genetics, полиморфизм G/A polymorphism of theF7 gene