CLINICAL AND EPIDEMIOLOGICAL FEATURES OF BOTULISM IN THE REPUBLIC OF UZBEKISTAN
Keywords:
botulism, botulinum toxin, neurotoxin, motoneuron, botulism antitoxin, Clostridium Botulinum.Abstract
Objectives. To study modern clinical and epidemiological features of the course
of botulism. Materials and methods. 64 patients with botulism aged from 7 to 60 years, who
were on in-patient treatment, were examined. The study was carried out on white mice,
which were injected intraperitoneally with a mixture of centrifuged blood serum of the
patient and botulism antitoxin of types A, B, E. Results. According to the results of the
botulinum toxin neutralization reaction, type A was found in 53 (63.8%) patients, type B
- in 15 (17.8%), type E - in 16 (18.3%); types B and E were registered in 17.8 and 18.3%,
respectively. The mild form of the disease is characterized by mild symptoms. The mediumheavy form proceeds with clearly expressed neurologic symptoms and acute respiratory
insufficiency, without signs of decompensation and complete preservation of swallowing.
Severe form is characterized by pronounced manifestation of all the symptoms of the
disease. Conclusion. Early signs in the beginning of the botulism clinic were mainly
neurological and diarrheal symptoms.
