INVESTIGATING UREMIC SYNDROME THROUGH EXPERIMENTAL MODELS IN RATS
Keywords:
Experimental uremic syndrome -- Rat -- 5/6 reduction of renal parenchyma Serum- and urine analysis -- Secondary hyperparathyroidism.Abstract
A chronic uremic syndrome was induced in rats through a 5/6 nephrectomy,
while an acute uremic syndrome was induced through bilateral nephrectomy. In the chronic
uremic syndrome, analysis of serum and urine revealed significantly elevated levels of BUN
and creatinine. Additionally, the animals exhibited chemical indicators characteristic of
secondary hyperparathyroidism. They experienced severe polyuria, proteinuria, and
albuminuria, although surprisingly, the total serum protein levels were increased. The
experimental chronic uremic syndrome can be described as a syndrome of "extreme
adaptation," affecting both the regulatory activity of the remaining renal parenchyma and
the overall body. On the other hand, the acute uremic syndrome induced by bilateral
nephrectomy is a severe disorder of water and electrolyte metabolism, ultimately leading to
the death of the experimental animals within 50-60 hours.
